THERMO SCIENTIF THERMO SCIENTIF

Listing description

The TSQ Quantum XLS and TSQ Quantum GC are members of the TSQ Quantum™ family of Thermo Scientific mass spectrometers. The TSQ Quantum XLS and the TSQ Quantum GC are advanced analytical instruments that include a mass spectrometer, liquid chromatograph, and the Xcalibur™ data system. In a typical analysis, an autosampler (AS) introduces a sample into the gas chromatograph (GC). The GC separates the sample into its various components. The components elute from the GC and pass into the mass spectrometer where they are analyzed. The TSQ Quantum XLS and TSQ Quantum GC mass spectrometers include an electron ionization/chemical ionization (EI/CI) ion source, ion optics, a triple-stage mass analyzer, and an ion detection system—all of which are enclosed in a vacuum manifold. Ionization of the sample takes place in the ion source. The specific process used to ionize the sample is known as the ionization mode. The ion optics transmit the ions produced in the ion source into the mass analyzer, where they are filtered according to their mass-to-charge ratio. The polarity of the potentials applied to the lenses in the ion source and ion optics determines whether positively charged ions or negatively charged ions are transmitted to the mass analyzer. You can configure the mass spectrometer to analyze positively or negatively charged ions (called the positive or negative ion polarity mode). The mass spectrometer’s triple-stage mass analyzer performs either one or two stages of mass analysis: • The mass spectrometer is operated as a conventional mass spectrometer with one stage of mass analysis. The ion source ionizes the sample and the ion products are subjected to mass analysis in the first rod assembly. The second and third rod assemblies transmit the resulting mass-selected ions to the ion detection system.1 • The mass spectrometer is operated as a tandem mass spectrometer with two stages of mass analysis. The ion source ionizes the sample and the ion products are mass analyzed by the first rod assembly. In this case, however, mass-selected ions exiting the first rod assembly collide with an inert gas in the second rod assembly and fragment to produce a set of ions known as product ions. (A chamber called the collision cell surrounds the second rod assembly. The collision cell can be pressurized with an inert gas.) The product ions undergo further mass analysis in the third rod assembly to detect selected ions. Two stages of mass analysis yield far greater chemical specificity than a single stage can achieve, because of the system’s ability to select and determine two discrete but directly related sets of masses. In a first stage of mass analysis, you can use the mass spectrometer to elucidate the structures of pure organic compounds and the structures of the components within mixtures. Furthermore, in a second stage of mass analysis, the mass spectrometer can fragment and separate each ionic fragment of a molecule formed in the ion source to build up an entire structure for the molecule, piece by piece. As a result, the TSQ Quantum XLS and the TSQ Quantum GC systems make investigating all pathways for the formation and fragmentation of each ion in the mass spectrum possible. The two stages of mass analysis, with resultant reduction of chemical noise in the final mass spectrum, allow for very selective and sensitive analysis. Each sequence of single or triple-stage mass analysis of the ions is called a scan. The mass spectrometer uses several different scan modes and different scan types to filter, fragment, or transmit ions in the mass analyzer. Along with the ionization and ion polarity modes, the ability to vary the scan mode and scan type affords you great flexibility in the instrumentation for solving complex analytical problems.

This equipment is located in US