Preowned freeze dryers and lyophilizers

Chamber volume	-6 L
Freeze trap capacity	90 L
Nbr of trays	6

Tray surface	1 m²
Minimal T°	60 °C

Chamber volume	20 L
Freeze trap capacity	5 L
Nbr of trays	2

Tray surface	0.2 m²
Minimal T°	40 °C

Chamber volume	11500 L
Nbr of trays	19

Tray surface	3.34 m²

Chamber volume	683 L
Minimal T°	-65 °C

Tray surface	1.02 m²
Nbr of trays	4

Chamber volume	645 L
Freeze trap capacity	2.2 L
Nbr of trays	6

Tray surface	0.36 m²
Minimal T°	-80 °C

Chamber volume	2000 L
Freeze trap capacity	100 L
Nbr of trays	15

Tray surface	1.08 m²
Minimal T°	-75 °C

Tray surface	6 m²

Tray surface	6 m²

Tray surface	5.8 m²
Nbr of trays	6

Freeze trap capacity	100 L

Chamber volume	10582 L
Minimal T°	130 °C

Tray surface	28.5 m²
Nbr of trays	16

Tray surface	28.8 m²
Nbr of trays	15

Freeze trap capacity	10 L

Tray surface	28.8 m²
Nbr of trays	15

Freeze trap capacity	10 L

Minimal T°	-80 °C

Nbr of trays	3

Chamber volume	10582 L
Minimal T°	130 °C

Tray surface	28.5 m²
Nbr of trays	16

Nbr of trays	24

Tray surface	13.9 m²
Nbr of trays	8

Minimal T°	-70 °C

Essential Guide to Lyophilizers in the Pharmaceutical and Chemical Industries

Lyophilizers, or freeze dryers, are indispensable in the pharmaceutical and chemical industries, essential for preserving and stabilizing sensitive products. This equipment removes water from materials through sublimation, which involves freezing the product, lowering the pressure, and converting ice directly into vapor. This process maintains the product's structure and composition, making lyophilizers vital for producing stable, long-lasting items like vaccines, biological samples, pharmaceuticals, and high-value chemicals.

Types of Lyophilizers

Laboratory Lyophilizers

Purpose: Small-scale freeze dryers for research, development, and pilot studies.
Applications: Formulation development, small batch production, and academic research.
Key Features: Compact design, precise control, and handling of small sample volumes.

Pilot Scale Lyophilizers

Purpose: Intermediate scale freeze dryers for process development and small-scale production.
Applications: Scale-up studies, process optimization, and limited production runs.
Key Features: Larger capacity, advanced control systems, and scalability for production purposes.

Production Scale Lyophilizers

Purpose: Large-scale freeze dryers for full-scale manufacturing.
Applications: Mass production of pharmaceuticals, biologicals, and chemicals.
Key Features: High capacity, robust design, automated operation, and regulatory compliance.

Industrial Lyophilizers

Purpose: Freeze dryers designed for industrial applications beyond pharmaceuticals, such as food processing and materials science.
Applications: Preservation of food products, stabilization of industrial chemicals, and material processing.
Key Features: High throughput, large chamber volumes, and heavy-duty construction.

Key Features and Specifications

When selecting a lyophilizer, consider these critical features and specifications:

Capacity: The volume or mass of product the lyophilizer can process per cycle, measured in liters or kilograms.
Temperature Range: Operating temperature range, including the lowest achievable shelf and condenser temperatures.
Vacuum System: Efficiency and reliability, affecting the drying rate and quality.
Control System: Advanced systems for precise monitoring and adjustment of process parameters.
Shelf Area and Configurations: Size and number of shelves, determining the total surface area available for product loading.
CIP (Clean-in-Place) and SIP (Sterilize-in-Place): Features for automated cleaning and sterilization, essential for maintaining sterility and GMP compliance.
Compliance and Validation: Ensure the lyophilizer meets regulatory standards like FDA, EMA, and ISO.
Automation and Data Logging: Automated processes and comprehensive data logging for process control, traceability, and validation.

Advantages of Using Lyophilizers

Investing in high-quality lyophilizers provides numerous benefits:

Preservation of Product Integrity: Maintains structural and chemical integrity of sensitive products.
Extended Shelf Life: Increases the shelf life of perishable materials by removing moisture.
Stability: Ensures uniform product quality with stable and consistent drying conditions.
Enhanced Purity: Reduces contamination risks, preserving the purity of pharmaceuticals and chemicals.
Scalability: Offers scalable solutions from laboratory to production scale.
Regulatory Compliance: Meets industry standards and regulations, essential for pharmaceutical and chemical manufacturing.

Considerations When Buying a Lyophilizer

To choose the right lyophilizer, consider these factors:

Product Characteristics: Understand the properties of the products to select a lyophilizer with suitable features.
Batch Size and Production Volume: Determine the required capacity and scale to match production needs.
Temperature and Pressure Requirements: Ensure the lyophilizer can achieve the necessary temperatures and vacuum levels for effective drying.
Regulatory Compliance: Verify that the lyophilizer meets all relevant regulatory standards.
Space and Installation: Consider space availability and any specific requirements for utilities and infrastructure.
Budget: Balance the initial investment with long-term operational costs, including maintenance and energy consumption.
Service and Support: Evaluate the availability of technical support, training programs, and maintenance services.
Future Expansion: Assess the machine’s scalability to meet potential increases in production demand.

Popular Brands and Pricing

Laboratory Lyophilizers

Labconco: Prices range from $10,000 to $50,000.
VirTis (SP Scientific): Pricing ranges from $15,000 to $60,000.
Millrock Technology: Prices fall between $12,000 and $55,000.

Pilot Scale Lyophilizers

GEA Group: Prices range from $50,000 to $200,000.
Telstar: Pricing ranges from $60,000 to $250,000.
Martin Christ: Prices fall between $55,000 and $220,000.

Production Scale Lyophilizers

SP Scientific (VirTis and Hull): Prices range from $200,000 to over $1 million.
IMA Life: Pricing ranges from $250,000 to over $1.5 million.
HOF Sonderanlagenbau: Prices fall between $300,000 and $2 million.

Industrial Lyophilizers

Harvest Right: Prices range from $20,000 to $150,000.
Cuddon Freeze Dry: Pricing ranges from $50,000 to $500,000.
SP Scientific (VirTis): Prices fall between $100,000 and $700,000.

Conclusion

Lyophilizers, or freeze dryers, are vital for preserving and stabilizing sensitive products in the pharmaceutical and chemical industries. Whether for laboratory research, pilot scale development, full-scale production, or industrial applications, choosing the right lyophilizer depends on specific production needs, product characteristics, and budget. Key factors include capacity, temperature range, vacuum system, control system, shelf area, compliance, and automation features. Leading brands like Labconco, VirTis (SP Scientific), Millrock Technology, GEA Group, Telstar, Martin Christ, IMA Life, HOF Sonderanlagenbau, Harvest Right, and Cuddon Freeze Dry offer high-quality lyophilizers to suit various applications and budgets. By carefully evaluating production requirements, product characteristics, and budget, businesses can invest in the right lyophilizer to enhance their production capabilities and ensure consistent, high-quality results.

Preowned freeze dryers and lyophilizers 32

terruzzi 6 mq Lyophilizer

EDWARDS MOD 1700 Lyophilizer

Freeze Dryer for Sale (Steris GT500)

SERAIL CS15-1 Lyophilizer

HOF GT laboratory freeze dryer / Lyo (2,16 m2) for vials with „stoppering“

CHRIST (GERMANY) Alpha 1-2 LDplus Laboratory freeze-dryer

LYOMAC FREEZE DRYER Low working hours

Usifroid SMH 604 Lyophilizer

Telstar VA-liof-101 Lyophilizer

Criofarma 30’000S Lyophilizer

OPTIMA FD D29 FREEZE DRYER

mp 20 kg Lyophilizer Hot deal

ThermoTEC Weilburg 2100 x 3000 x 2310mm Lyophilizer

Usifroid SMH Lyophilizer

Usifroid SMH Lyophilizer

ThermoTEC Weilburg TCS 1001 Lyophilizer

Edwards MINI-FAST 1700 Lyophilizer

Used OPTIMA FD D29 Lyophilizer

Turkish made freeze dryer with 24 trays

Lyophilizer, freeze dryer for vials Edwards 2-СF (Two cameras area for each 13.9 sq.m.)

Essential Guide to Lyophilizers in the Pharmaceutical and Chemical Industries

Types of Lyophilizers

Laboratory Lyophilizers

Pilot Scale Lyophilizers

Production Scale Lyophilizers

Industrial Lyophilizers

Key Features and Specifications

Advantages of Using Lyophilizers

Considerations When Buying a Lyophilizer

Popular Brands and Pricing

Laboratory Lyophilizers

Pilot Scale Lyophilizers

Production Scale Lyophilizers

Industrial Lyophilizers

Conclusion

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